The problem with Ronald Colman (1891-1958) was that he made acting look too easy. In 1935 he was cast as Sidney Carton, the hero of M-G-M’s A Tale of Two Cities. Colman’s performance is as impressive today as it was when first seen more than 70 years ago.
It’s one thing to make a raunchy comedy. It’s another to tell a serious story about someone coping with a life-threatening disease. 50/50 puts those two genres together so that they complement rather than cancel each other.